Year Graduated: 2009

Student's Name Thesis Advisor(s) List of Published Papers During Study Time
**Equally Contributing Authors
* Corresponding Author(s)
Wei-Chi Ku ¶d­³´¼ Dr. Yu-Ju Chen
  1. Wei-Chi Ku, S.K. Chiu, Y.J. Chen, H.H. Huang, W.G. Wu, and Y.J. Chen, (2009) Complementary Quantitative Proteomics Reveals that Transcription Factor AP-4 Mediates E-Box-Dependent Complex Formation for Transcriptional Repression of HDM2, Mol. Cell. Proteomics, in press.
  2. Y.J. Chen, Wei-Chi Ku, L.T. Feng, M.L. Tsai, C.H. Hsieh, W.H. Hsu, W.F. Liaw, C.H. Hung, and Y.J. Chen, (2008) Nitric Oxide Physiological Responses and Delivery Mechanisms Probed by Water-soluble Roussin¡¦s Red Ester and {Fe(NO)2}10 DNIC, J. Am. Chem. Soc., 130,10929.
Chih-Jung Kuo ³¢­Pºa Dr. Po-Huang Liang
  1. Hsu MF*, Kuo CJ*, Chang KT, Chang HC, Chou CC, Ko TP, Shr HL, Chang GG, Wang AH, Liang PH. (2005) Mechanism of the maturation process of SARS-CoV 3CL protease. J Biol Chem. 280(35):31257-66.
  2. Guo RT, Ko TP, Chen AP, Kuo CJ, Wang AH, Liang PH. (2005) Crystal structures of undecaprenyl pyrophosphate synthase in complex with magnesium, isopentenyl pyrophosphate, and farnesyl thiopyrophosphate: roles of the metal ion and conserved residues in catalysis. J Biol Chem. 280(21):20762-74
  3. Chen LR, Wang YC, Lin YW, Chou SY, Chen SF, Liu LT, Wu YT, Kuo CJ, Chen TS, Juang SH. (2005) Synthesis and evaluation of isatin derivatives as effective SARS coronavirus 3CL protease inhibitors. Bioorg Med Chem Lett. 15(12):3058-62
  4. Shie JJ, Fang JM, Kuo CJ, Kuo TH, Liang PH, Huang HJ, Yang WB, Lin CH, Chen JL, Wu YT, Wong CH. (2005) Discovery of potent anilide inhibitors against the severe acute respiratory syndrome 3CL protease. J Med Chem. 48(13):4469-73
  5. Shie JJ, Fang JM, Kuo TH, Kuo CJ, Liang PH, Huang HJ, Wu YT, Jan JT, Cheng YS, Wong CH. (2005) Inhibition of the severe acute respiratory syndrome 3CL protease by peptidomimetic alpha,beta-unsaturated esters. Bioorg Med Chem. 13(17):5240-52
  6. Sun HY, Ko TP, Kuo CJ, Guo RT, Chou CC, Liang PH, Wang AH. (2005) Homodimeric hexaprenyl pyrophosphate synthase from the thermoacidophilic crenarchaeon Sulfolobus solfataricus displays asymmetric subunit structures. J Bacteriol. 187(23):8137-48
  7. Wu CY, King KY, Kuo CJ, Fang JM, Wu YT, Ho MY, Liao CL, Shie JJ, Liang PH, Wong CH. (2006) Stable benzotriazole esters as mechanism-based inactivators of the severe acute respiratory syndrome 3CL protease. Chem Biol. 13(3):261-8
  8. Lu IL, Mahindroo N, Liang PH, Peng YH, Kuo CJ, Tsai KC, Hsieh HP, Chao YS, Wu SY. (2006) Structure-based drug design and structural biology study of novel nonpeptide inhibitors of severe acute respiratory syndrome coronavirus main protease. J Med Chem. 49(17):5154-61.
  9. Guo RT, Cao R, Liang PH, Ko TP, Chang TH, Hudock MP, Jeng WY, Chen CK, Zhang Y, Song Y, Kuo CJ, Yin F, Oldfield E, Wang AH. (2007) Bisphosphonates target multiple sites in both cis- and trans-prenyltransferases. Proc Natl Acad Sci U S A. 104(24):10022-7.
  10. Wen CC, Kuo YH, Jan JT, Liang PH, Wang SY, Liu HG, Lee CK, Chang ST, Kuo CJ, Lee SS, Hou CC, Hsiao PW, Chien SC, Shyur LF, Yang NS. (2007) Specific plant terpenoids and lignoids possess potent antiviral activities against severe acute respiratory syndrome coronavirus. J Med Chem. 50(17):4087-95
  11. Lee CC, Kuo CJ, Hsu MF, Liang PH, Fang JM, Shie JJ, Wang AHJ. (2007) Structural basis of mercury- and zinc-conjugated complexes as SARS-CoV 3C-like protease inhibitors. FEBS Lett. 581(28):5454-8
  12. Kuo CJ, Guo RT, Lu IL, Liu HG, Wu SY, Ko TP, Wang AH, Liang PH. (2008) Structure-based inhibitors exhibit differential activities against Helicobacter pylori and Escherichia coli undecaprenyl pyrophosphate synthases. J Biomed Biotechnol. 2008:841312.